罗智璞 教授

罗智璞，新威尼斯v0008分子酶学研究所特聘教授，博士生导师。2006年获湖北大学生命科学学院化学生物学专业理学学士学位，2012年获中国科学院福建物质结构研究所生物化学与分子生物学博士学位。2012年10月至2017年10月，在美国国立癌症研究所/阿贡国家实验室从事博士后研究工作。2017年12月至2018年4月，在清华大学生命学院任助理研究员。2018年5月入职新威尼斯v0008。近年来在Science，Nature，Nature Neuroscience，Nature Commnunications，Cell Research，PNAS, JACS，Nucleic Acids Research等知名期刊上发表论文30多篇。在生物大分子晶体结构解析方面有非常丰富的经验，应邀在2018年第十七届国际生物大分子结晶大会相位解析培训班和2021年上海光源蛋白质晶体线站及数据处理还原新技术讲习班讲授生物大分子晶体学相关内容。目前主要从事病毒核酸诱导的先天性免疫的调控机制研究。

代表论文：

1. 生物大分子的结构与功能研究

2. 蛋白质与核酸的相互作用研究

发表论文：

https://pubmed.ncbi.nlm.nih.gov/?term=Zhipu+Luo

1.  Structure-based discovery of nonhallucinogenic psychedelic analogs.

Cao D, Yu J, Wang H, Luo Z, Liu X, He L, Qi J, Fan L, Tang L, Chen Z, Li J, Cheng J, Wang S.

Science. 2022 Jan 28;375(6579):403-411. doi: 10.1126/science.abl8615.  

Science文章｜以结构为导向改造致幻剂以治疗抑郁症

2.  Structure-based design of a novel third-generation antipsychotic drug lead with potential antidepressant properties.

Chen Z, Fan L, Wang H, Yu J, Lu D, Qi J, Nie F, Luo Z, Liu Z, Cheng J, Wang S.

Nat Neurosci. 2022 Jan;25(1):39-49. doi: 10.1038/s41593-021-00971-w.  

3.  Crystal structure of parallel G-quadruplex formed by the two-repeat ALS- and FTD-related GGGGCC sequence.

Geng Y, Liu C, Cai Q, Luo Z, Miao H, Shi X, Xu N, Fung CP, Choy TT, Yan B, Li N, Qian P, Zhou B, Zhu G.

Nucleic Acids Res. 2021 Jun 4;49(10):5881-5890. doi: 10.1093/nar/gkab302.

4.  Unexpected organic hydrate luminogens in the solid state.

Zhou F, Gu P, Luo Z, Bisoyi HK, Ji Y, Li Y, Xu Q, Li Q, Lu J.

Nat Commun. 2021 Apr 20;12(1):2339. doi: 10.1038/s41467-021-22685-0.

5.  Assembly of Nanofluidic MXene Fibers with Enhanced Ionic Transport and Capacitive Charge Storage by Flake Orientation.

Li S, Fan Z, Wu G, Shao Y, Xia Z, Wei C, Shen F, Tong X, Yu J, Chen K, Wang M, Zhao Y, Luo Z, Jian M, Sun J, Kaner RB, Shao Y.

ACS Nano. 2021 Apr 27;15(4):7821-7832. doi: 10.1021/acsnano.1c02271. Epub 2021 Apr 9.

6.  A conserved LDL-receptor motif regulates corin and CD320 membrane targeting in polarized renal epithelial cells.

Zhang C, Chen Y, Sun S, Zhang Y, Wang L, Luo Z, Liu M, Dong L, Dong N, Wu Q.

Elife. 2020 Nov 2;9:e56059. doi: 10.7554/eLife.56059.

7.  Haloperidol bound D2 dopamine receptor structure inspired the discovery of subtype selective ligands.

Fan L, Tan L, Chen Z, Qi J, Nie F, Luo Z, Cheng J, Wang S.

Nat Commun. 2020 Feb 26;11(1):1074. doi: 10.1038/s41467-020-14884-y.

8.  Structural basis of ligand recognition and self-activation of orphan GPR52.

Lin X, Li M, Wang N, Wu Y, Luo Z, Guo S, Han GW, Li S, Yue Y, Wei X, Xie X, Chen Y, Zhao S, Wu J, Lei M, Xu F.

Nature. 2020 Mar;579(7797):152-157. doi: 10.1038/s41586-020-2019-0. Epub 2020 Feb 19.

9.  Programming Conventional Electron Microscopes for Solving Ultrahigh-Resolution Structures of Small and Macro-Molecules.

Zhou H, Luo F, Luo Z, Li D, Liu C, Li X.

Anal Chem. 2019 Sep 3;91(17):10996-11003. doi: 10.1021/acs.analchem.9b01162. Epub 2019 Aug 15.

10.  Using focus ion beam to prepare crystal lamella for electron diffraction.

Zhou H, Luo Z, Li X.

J Struct Biol. 2019 Mar 1;205(3):59-64. doi: 10.1016/j.jsb.2019.02.004. Epub 2019 Feb 20.

11.  Allosteric enhancement of ORP1-mediated cholesterol transport by PI(4,5)P2/PI(3,4)P2.

Dong J, Du X, Wang H, Wang J, Lu C, Chen X, Zhu Z, Luo Z, Yu L, Brown AJ, Yang H, Wu JW.

Nat Commun. 2019 Feb 19;10(1):829. doi: 10.1038/s41467-019-08791-0.

12.  Bioactive Functionalized Monolayer Graphene for High-Resolution Cryo-Electron Microscopy.

Liu N, Zhang J, Chen Y, Liu C, Zhang X, Xu K, Wen J, Luo Z, Chen S, Gao P, Jia K, Liu Z, Peng H, Wang HW.

J Am Chem Soc. 2019 Mar 6;141(9):4016-4025. doi: 10.1021/jacs.8b13038. Epub 2019 Feb 20.

13.  Amyloid fibril structure of α-synuclein determined by cryo-electron microscopy.

Li Y, Zhao C, Luo F, Liu Z, Gui X, Luo Z, Zhang X, Li D, Liu C, Li X.

Cell Res. 2018 Sep;28(9):897-903. doi: 10.1038/s41422-018-0075-x. Epub 2018 Jul 31.

14.  The crystal structure of Z-DNA with untypically coordinated Ca2+ ions.

Luo Z, Dauter Z.

J Biol Inorg Chem. 2018 Mar;23(2):253-259. doi: 10.1007/s00775-017-1526-4. Epub 2017 Dec 21.

15.  Crystal Structure of Borrelia turicatae protein, BTA121, a differentially regulated gene in the tick-mammalian transmission cycle of relapsing fever spirochetes.

Luo Z, Kelleher AJ, Darwiche R, Hudspeth EM, Shittu OK, Krishnavajhala A, Schneiter R, Lopez JE, Asojo OA.

Sci Rep. 2017 Nov 10;7(1):15310. doi: 10.1038/s41598-017-14959-9.

16.  Four highly pseudosymmetric and/or twinned structures of d(CGCGCG)2 extend the repertoire of crystal structures of Z-DNA.

Luo Z, Dauter Z, Gilski M.

Acta Crystallogr D Struct Biol. 2017 Nov 1;73(Pt 11):940-951. doi: 10.1107/S2059798317014954. Epub 2017 Oct 30.

17.  Crystal Structure of MpPR-1i, a SCP/TAPS protein from Moniliophthora perniciosa, the fungus that causes Witches' Broom Disease of Cacao.

Baroni RM, Luo Z, Darwiche R, Hudspeth EM, Schneiter R, Pereira GAG, Mondego JMC, Asojo OA.

Sci Rep. 2017 Aug 10;7(1):7818. doi: 10.1038/s41598-017-07887-1.

18.  Embarras de richesses - It is not good to be too anomalous: Accurate structure of selenourea, a chiral crystal of planar molecules.

Luo Z, Dauter Z.

PLoS One. 2017 Feb 16;12(2):e0171740. doi: 10.1371/journal.pone.0171740. eCollection 2017.

19.  Structural insights into RNA duplexes with multiple 2΄-5΄-linkages.

Shen F, Luo Z, Liu H, Wang R, Zhang S, Gan J, Sheng J.

Nucleic Acids Res. 2017 Apr 7;45(6):3537-3546. doi: 10.1093/nar/gkw1307.

20.  Selenourea: a convenient phasing vehicle for macromolecular X-ray crystal structures.

Luo Z.

Sci Rep. 2016 Nov 14;6:37123. doi: 10.1038/srep37123.

21.  Crystal structures of the ligand-binding region of uPARAP: effect of calcium ion binding.

Yuan C, Jürgensen HJ, Engelholm LH, Li R, Liu M, Jiang L, Luo Z, Behrendt N, Huang M.

Biochem J. 2016 Aug 1;473(15):2359-68. doi: 10.1042/BCJ20160276. Epub 2016 May 31.

22.  Multifunctional Charge-Transfer Single Crystals through Supramolecular Assembly.

Xu B, Luo Z, Wilson AJ, Chen K, Gao W, Yuan G, Chopra HD, Chen X, Willets KA, Dauter Z, Ren S.

Adv Mater. 2016 Jul;28(26):5322-9. doi: 10.1002/adma.201600383. Epub 2016 May 4.

23.  Base pairing and structural insights into the 5-formylcytosine in RNA duplex.

Wang R, Luo Z, He K, Delaney MO, Chen D, Sheng J.

Nucleic Acids Res. 2016 Jun 2;44(10):4968-77. doi: 10.1093/nar/gkw235. Epub 2016 Apr 13.

24.  Luo Z, Dauter Z.(2016) Detection of twinning in macromolecular crystallography, Zeitschrift fuer Kristallographie, 231(10): 561-571 (IF=3.179)

25.  Design of Specific Serine Protease Inhibitors Based on a Versatile Peptide Scaffold: Conversion of a Urokinase Inhibitor to a Plasma Kallikrein Inhibitor.

Xu P, Xu M, Jiang L, Yang Q, Luo Z, Dauter Z, Huang M, Andreasen PA.

J Med Chem. 2015 Nov 25;58(22):8868-76. doi: 10.1021/acs.jmedchem.5b01128. Epub 2015 Nov 12.

26.  Stabilizing a flexible interdomain hinge region harboring the SMB binding site drives uPAR into its closed conformation.

Zhao B, Gandhi S, Yuan C, Luo Z, Li R, Gårdsvoll H, de Lorenzi V, Sidenius N, Huang M, Ploug M.

J Mol Biol. 2015 Mar 27;427(6 Pt B):1389-1403. doi: 10.1016/j.jmb.2015.01.022. Epub 2015 Feb 7.

27.  Phosphates in the Z-DNA dodecamer are flexible, but their P-SAD signal is sufficient for structure solution.

Luo Z, Dauter M, Dauter Z.

Acta Crystallogr D Biol Crystallogr. 2014 Jul;70(Pt 7):1790-800. doi: 10.1107/S1399004714004684. Epub 2014 Jun 24.

28.  Weak data do not make a free lunch, only a cheap meal.

Luo Z, Rajashankar K, Dauter Z.

Acta Crystallogr D Biol Crystallogr. 2014 Feb;70(Pt 2):253-60. doi: 10.1107/S1399004713026680. Epub 2014 Jan 17.

29.  Structural mechanism of ring-opening reaction of glucose by human serum albumin.

Wang Y, Yu H, Shi X, Luo Z, Lin D, Huang M.

J Biol Chem. 2013 May 31;288(22):15980-7. doi: 10.1074/jbc.M113.467027. Epub 2013 Apr 16.

30.  Investigation on the site-selective binding of bovine serum albumin by erlotinib hydrochloride.

Liu Y, Chen M, Luo Z, Lin J, Song L.

J Biomol Struct Dyn. 2013 Oct;31(10):1160-74. doi: 10.1080/07391102.2012.726532. Epub 2012 Oct 17.

31.  Enhanced photodynamic efficacy of zinc phthalocyanine by conjugating to heptalysine.

Li L, Luo Z, Chen Z, Chen J, Zhou S, Xu P, Hu P, Wang J, Chen N, Huang J, Huang M.

Bioconjug Chem. 2012 Nov 21;23(11):2168-72. doi: 10.1021/bc3002997. Epub 2012 Oct 22.

32.  Structural evidence of perfluorooctane sulfonate transport by human serum albumin.

Luo Z, Shi X, Hu Q, Zhao B, Huang M.

Chem Res Toxicol. 2012 May 21;25(5):990-2. doi: 10.1021/tx300112p. Epub 2012 Apr 16.

33.  A fluorescent fatty acid probe, DAUDA, selectively displaces two myristates bound in human serum albumin.

Wang Y, Luo Z, Shi X, Wang H, Nie L, Huang M.

Protein Sci. 2011 Dec;20(12):2095-101. doi: 10.1002/pro.749. Epub 2011 Nov 9.

34.  Structural basis for recognition of urokinase-type plasminogen activator by plasminogen activator inhibitor-1.

Lin Z, Jiang L, Yuan C, Jensen JK, Zhang X, Luo Z, Furie BC, Furie B, Andreasen PA, Huang M.

J Biol Chem. 2011 Mar 4;286(9):7027-32. doi: 10.1074/jbc.M110.204537. Epub 2011 Jan 3.

35.  Pentalysine beta-carbonylphthalocyanine zinc: an effective tumor-targeting photosensitizer for photodynamic therapy.

Chen Z, Zhou S, Chen J, Deng Y,Luo Z, Chen H, Hamblin MR, Huang M.

ChemMedChem. 2010 Jun 7;5(6):890-8. doi: 10.1002/cmdc.201000042.