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个人信息
个人简介
个人简介 研究工作经历 (1) 2014.7-至今, 新威尼斯v0008, 基础医学与生物科学院, 教授,博士生导师 (2) 2013.4-2014.6, The Scripps Research Institute.USA, Cancer Biology,Young Excellent Teacher Visiting Scholar. (3) 2006.12-2013.3, 新威尼斯v0008, 基础医学与生物科学院, 副教授,硕士生导师 (4) 2004.7-2005.12, 清华大学, 生命科学学院, 访问学者 (5) 2003.6-2004.6, The University of Newcastle, Australia, Department of Biomedical Sciences,Visiting Scholar. (6) 1990.9-2003.5, 山东农业大学, 生命科学院, 副教授 (7) 1988.9-1990.7, 武汉大学, 化学系, 讲师 (8) 1986.7-1988.8, 山东农业大学, 生命科学院, 助教 (9) 1982.9-1986.7,山东师范大学,化学系,学生 社会兼职 新威尼斯v0008-复鑫益 蛭肽蛋白协同创新中心 副主任 研究领域
(1) 蛋白质的结构和功能 基本信息
职称:教授 院部/部门:苏州医学院基础医学院 学历:博士 学位: 毕业学校: 毕业专业: 联系方式
通讯地址: 邮政编码: 电子邮箱:hhy2469@126.com 联系电话:0512-65880279 传真号码: 办公地点:医学部新威尼斯v0008 科学研究
主要研究酶蛋白的结构和功能,与酶相互作用蛋白的调控机制,酶抑制剂设计和筛选。研究丝素蛋白构象调控对其功能的影响。在应用领域致力于功能蛋白(肽)的开发,研发了蛭肽等多种功能蛋白产品。近年承担的主要研究项目: 科研团队
教师:许维岸教授,汪成富副教授,顾福根副教授 论文
由中国科学技术出版社等出版编著和著作4部,国内外杂志发表论文百余篇。近年发表的主要论文(*通讯作者): 1. HongyanHan,Longsheng Dua , Zhifei Caoa,Bin Zhanga,Quansheng Zhou.Triptonidepotently suppresses pancreatic cancer cell-mediated vasculogenic mimicry byinhibiting expression of VE-cadherin and chemokine ligand 2 genes.EuropeanJournal of Pharmacology, 2018.1, 818: 593~603 2. Bin Zhang ,HongyanHan*, Quansheng Zhou,Shilong Fu,Ping Yang,Zhenlun Gu, Zhifei Cao,Dehydroeffusol inhibits gastric cancer cell growth and tumorigenicity byselectively inducing tumor-suppressive endoplasmic reticulum stress and amoderate apoptosis. Biochemical Pharmacology, 2016.3.15, 104:8~18 3.Han H , Ning H , Liu S , Lu Q , Fan Z , Lu H , Lu G ,Kaplan DL . Silk Biomaterials with Vascularization Capacity. Advanced FunctionalMaterials, 2016 Jan;26 (3): 421-436 4.H Han, S Bai,X Huang,W Xu, DL Kaplan , Lu Q. Silkscaffolds with tunable mechanical capability for cell differentiation. ActaBiomaterialia .2015,20(1):22-31 5.. Yue-Xiu Si , Sunyoung Ji , Wei Wanga, Nai-Yun Fanga,Qing-Xin Jin , Yong-Doo Parkd,Guo-Ying Qian, Jinhyuk Leeb, Hong-Yan Han*,Shang-Jun Yin; Effects of boldineon tyrosinase: Inhibition kinetics and computational simulation; ProcessBiochemistry; 2013;48;152–161 6.. Chao Li , Yu-huaChen, Zhen-wang Zhang, Cheng-liang Gong,Hong-yanHan*, Wei-an Xu;Glu434 is animportant amino acid residue for the activity, structure and stability oftyrosine hydroxylase of the silkworm, Bombyx mori; Process Biochemistry; 2013; 48 ;1665–1673 7. Chao-Jun Pei,Jinhyuk Lee, Yue-Xiu Si , Sangho Oh, Wei-An Xu, Shang-Jun Yin, Guo-Ying Qian,, Hong-Yan Han*; Inhibition of tyrosinase by gastrodin: Anintegrated kinetic-computational simulation analysis; ProcessBiochemistry ;2013;48; 162–168 8. Xiao-Xia Liu ,Shi-Qing Sun ,Yu-Jie Wang, Wei Xu, Yi-Fang Wang , Daeui Park, Hai-Meng Zhou , Hong-Yan Han*. Kinetics and Computational Docking Studies on the Inhibition ofTyrosinase Induced by Oxymatrine; Appl Biochem Biotechnol;2013; 169;145–158 9. S. Bai, S. Liu, C.Zhang, W. Xub, Q. Lu, H. Han*, D.L Kaplan c, H. Zhu; Controllable transition of silk fibroin nanostructures: An insightinto in vitro silk self-assembly process; Acta Biomaterialia 2013;9; 7806–7813 10. Hong-Yan Han , He-Chang Zou, Jun-Yeong Jeon, Ye-Jing Wang,Wei-An Xu, Jun-Mo Yang ,Yong-Doo Park; The inhibition kinetics and thermodynamic changes of tyrosinase viathe zinc ion; Biochimica et Biophysica Acta; 2007;1774; 822–827 11. Hong-Yan Han, Jae-Rin Lee, Wei-An Xu, Myong-Joon Hah,Jun-Mo Yang, Yong-Doo Park;Effect of Cl- on Tyrosinase: Complex Inhibition Kinetics andBiochemical Implication;Journal of Biomolecular Structure & Dynamics; 2007; 25;2,165-171 12. Hong-Yan Han,Wei-An Xu,Zhi-Rong Lü,Fei Zou,Sen Li; Activation and Inactivation of orseradishPeroxidase by Cobalt Ions; Journal of Biomolecular Structure & Dynamics;2008;26;1;83-91 13. Hong-Yan Han,Zhi-Gang Yao,Cheng-LiangGong,Wei-An Xu;The Protective Effects of Osmolytes On Yeast AlcoholDehydrogenase Comformational Stability And Aggregation; protein & peptideletter;2010;17;1058-1066 14.Wei-An Xu,Hong-Yan Han*;A Survey Of The Genera Of MicrogasterLatreille And Hygroplitis AndHygroplitis Thomson(Hymenoptera:Braconidae:Microgastrinae) From China;Phytoparasitica; 2007; 35;1;86-99 荣誉奖励
开授课程
1.生物化学 招生信息
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